Treatment of children with HCV
This section contains the SIGN guidance for the treatment of children with HCV and an overview of the supporting evidence.
Treatment of children with hepatitis c
Response rates to treatment in children are of a similar magnitude, and show the same influences of genotype, to adults.59 Combination treatment with interferon (IFN) and ribavirin gives an overall SVR of 50-60%.59-62 Data on the use of pegylated interferon, as opposed to standard interferon, and on optimal dosage and adverse sequelae in children are limited. There is a potential for effects on thyroid function and growth problems.61, 62 3
Children with evidence of moderate or severe liver disease should be considered for treatment with pegylated IFN and ribavirin.
In children who are asymptomatic with mild or no liver disease, benefits of treatment need to be weighed against the risk of side effects.
Good practice points
Children infected with HCV should be managed in consultation with a paediatric service with specialist expertise in hepatitis C.
